Download E-books Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications (Wiley Series in Drug Discovery and Development) PDF

By Binghe Wang

Brings jointly useful and structural informationrelevant to the layout of gear focusing on zinc enzymesThe moment such a lot considerable transition aspect in residing organisms, zinc spans all components of metabolism, with zinc-containing proteins delivering either demonstrated and capability drug ambitions. Drug layout of Zinc-Enzyme Inhibitors brings jointly useful and structural details appropriate to those zinc-containing pursuits. With updated overviews of the most recent advancements box, this precise and entire textual content allows readers to appreciate zinc enzymes and evaluation them in a drug layout context.With contributions from the leaders of latest examine, Drug layout of Zinc-Enzyme Inhibitors covers such key themes as:Major drug pursuits like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3GRoles of lately came across zinc-containing isozymes in melanoma, weight problems, epilepsy, discomfort administration, malaria, and different conditionsCross reactivity of zinc-enzyme inhibitors and activatorsThe wide use of X-ray crystallography and QSAR reviews for figuring out zinc-containing proteinsClinical applicationsAn crucial source for the invention and improvement of latest drug molecules, Drug layout of Zinc-Enzyme Inhibitors supplies researchers, pros, scholars, and teachers the basis to appreciate and paintings with zinc enzyme inhibitors and activators.

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